DMPS is administered over a five-minute period since hypotensive effects are possible when given intravenously as a bolus. Zinc is particularly important when undergoing mercury chelation. Even though DMPS has a high affinity for mercury, the highest affinity appears to be for copper and zinc and supplementation needs to be used to not avoid depleting these beneficial minerals. This will minimize any potential toxicity from the DMPS. Ideally DMPS should be administered after 25 grams of ascorbic acid administered intravenously. One should use DMPS with great CAUTION and NEVER use it in patients with amalgam fillings. Ideally intravenous DMPS should never be used in patients that still have amalgam fillings in place, although investigators have done this as diagnostically, as a one-time dose, without complications.76 DMPS appears in the saliva and may mobilize significant amounts of mercury from the surface of the fillings and precipitate seizures, cardiac arrhythmias, or severe fatigue. Mercury exposure has also been associated with other neurological problems such as tremors, insomnias, polyneuropathy, paresthesia, emotional lability, irritability, personality changes, headaches, weakness, blurred vision, dysarthria, slowed mental response and unsteady gait.ĭMPS is not mutagenic, teratogenic or carcinogenic. Mercury has recently been documented to be associated with arrhythmias and cardiomyopathies as hair analysis showed mercury levels to be 20,000 higher in those with these cardiac abnormalities. There has been a recent epidemic of autism in the US and many investigators believe that this may be partially related to the increased exposure infants have had to mercury through the preservative thimerosal that was included in nearly all vaccines until recently.The nervous system is more sensitive to mercury toxicity than any other organ in the body. Amalgam use may also be related to fatigue, poor memory and certain psychological disorders. Subclinical neuropsychological and motor control effects were also observed in dentists who had documented high mercury exposure levels. Patients with many amalgam fillings will also have an increase in the prevalence of antibiotic resistant bacteria. The scientific literature shows that amalgam fillings have been associated with a variety of problems such as Alzheimer's Disease, autoimmunity, kidney dysfunction, infertility, polycystic ovary syndrome, neurotransmitter imbalances, food allergies, multiple sclerosis, thyroid problems, and an impaired immune system. Mercury Toxicity SymptomsThe overt clinical effects resulting from toxic exposure to mercury have been clearly described. Unless actively removed, mercury has an extremely long half-life of somewhere between 15 and 30 years in the CNS. Other studies have shown that mercury is taken up in the periphery by all nerve endings and rapidly transported inside the axon of the nerves (axonal transport) to the spinal cord and brainstem. Mercury bonds very firmly to structures in the CNS through its affinity for sulfhydryl-groups on amino acids. Mercury in the central nervous system (CNS) causes psychological, neurological, and immunological problems in humans. Chewing, brushing, and the intake of hot fluids stimulates this release. The mercury escapes continuously during the entire life of the filling primarily in the form of vapor, ions but also abraded particles. It is clear that amalgam mercury transfers to human tissues, accumulates with time, and presents a potential health threat. The vapor serves as the primary route of mercury from amalgams into the body. The mercury vapor from the amalgams is lipid soluble and passes readily through cell membranes and across the blood brain barrier. as over 90% of dentists use them for restoring posterior teeth. More than 100 million mercury fillings are placed each year in the U.S. The amalgam also consists of 35% silver, 9% tin, 6% copper and a trace of zinc. A "silver" filling, or dental amalgam, is not a true alloy. Currently, Germany, Sweden and Denmark severely restrict the use of amalgams. By way of contrast, estimates of the daily absorption of all forms of mercury from fish and seafood is 2.3 micrograms and from all other foods, air and water is 0.3 micrograms per day. These levels are consistent with reports of 60 micrograms of mercury per day collected in human feces. The average individual has eight amalgam fillings and could absorb up to 120 micrograms of mercury per day from their amalgams. A single dental amalgam filling with a surface area of only 0.4 sq.cm is estimated to release as much as 15 micrograms of mercury per day primarily through mechanical wear and evaporation.
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